【 Cartridge detection 】 The test medicinal lu: su composite membrane materials

Abstract: drug easy deliquescence metamorphic water, medicinal aluminum-plastic composite membrane should have high resistance to wet, the lower the water vapor transmittance, shows that the higher the resistance properties of the packaging material, for drugs with good protective. Medicinal lu: su composite film knead this article detailed introduces the test and how to monitor the resistance properties of the packaging materials before and after rubbing, provide the technical reference for industry users. Keywords: drugs, aluminum-plastic composite membrane, knead performance, resistance to wet, moisture permeability, water vapor barrier, water vapor transmittance, deliquescence metamorphic testing: drug safety itself is crucial, so foreign performance requirements of packaging materials also is higher, especially the packaging material to the outside world water vapor barrier performance, which can effectively prevent medicine were deliquescence. Lu: su composite film packaging can be used as a powder or blister packaging drug package base plate material, in addition to make pharmaceutical packaging has beautiful and good texture, the most important is to have the advantages of the high barrier property. And was also involved in the gas through the plastic layer in the composite film, for the whole of composite membrane barrier property also have certain effect, but not decisive, unless the aluminum foil pinhole size compared with other composite layer thickness is large enough, the barrier property of composite membrane will be affected by the plastic film layer thickness and the blocking performance is obvious. In addition, lu: su composite film of aluminum foil layer easily in packaging forming, filling, heat sealing, and a certain degree of crease appeared in the process of transporting and selling, so that the barrier property of composite membrane, finished product packaging of whole sealing be badly affected. Detection: rub resistance of flexible composite film testing follow ASTM F392 'flexible block material bending durability test method of the standard, the use of special of rubbing tester in the condition of normal atmospheric pressure, 23 ℃ and 50% relative humidity) Next to up and down reciprocating composite membrane and repeat distorted knead, knead the intensity of a quake as soon as the condition, number and knead according to the material of the test samples and the actual use process, but the speed of the fixed frequency for 45 times/min. We will use Labthink lincom company independent research and development of FDT - 02 rubbing tester according to the above standard medicinal aluminum-plastic composite membrane samples rub test. The RuanSu packaging resistance properties of the common testing methods are divided into weighing method ( Also known as the cup method) Method and sensor method, of which the sensor is divided into electrolytic process and humidity method and infrared method. Weighing method based methods are widely used in pharmaceutical packaging material of water vapor transmittance detection, through accurately weighing a certain temperature and humidity environment, sample after reach water vapor through the balance, the clamping with moisture vapor transmission cup quality before and after the change of the sample, and sample water vapor transmittance is calculated. At present, the domestic weighing method testing water vapor transmittance follow GB1037 - 1988 'plastic film and sheet of water vapour permeability test method cup type act the national standard. 1, test instruments Labthink lincom r &d and production of FDT - 02 rub tester, with five kinds of standard test mode, four sample location easily implement the combined test under different conditions, and can realize quickly switch between long and short trip. The instrument to meet the ASTM F392 foreign standards, can be applied to a variety of purposes under the flexible film, composite membrane, lu: su composite film, aluminum plating film, coating film materials such as rubbing resistance test, simulation film knead in the process of production, processing, transportation, fold the pressure damage, etc. After the rub test, through the pinhole in the number of changes before and after the test sample or the change of the blocking performance judgment rub resistance of materials. W3/060 water vapor transmittance test system, six independent cavity, high test accuracy, can test 6 pieces of the same or different samples at the same time, control temperature range of 15 ℃ ~ 55 ℃, humidify range is 10% RH to 98% RH, water vapor transmittance test scope for ( 0. 1-10000) g/m2• 24 h, the system can support up to 10 instrument in parallel connection, set up 60 samples and test's system of high efficiency. The instrument can meet all kinds of plastic film, composite film under different temperature and humidity environment, paper-plastic composite membrane, co-extrusion film, aluminum plating film, aluminum foil, aluminum-plastic composite membrane, waterproof breathable membrane and membrane material and sheet of water vapor barrier property test. 2. Sample preparation of the FDT - 02 rubbing tester of aluminum-plastic composite film sample C mode 6 minutes 270 times repeatedly rub, rub knead after samples and not intact samples under 23 ℃ environment, on the dryer regulating state within 48 hours. After remove rub before and after the two samples, respectively from each sample slice the diameter of 74 mm on three samples. 3. Test conditions where: jinan lincom packaging safety testing center test temperature and humidity: 38 ℃, 90% RH test method: weighing method ( The cup method) 4. Step 4. Moisture vapor transmission cup 1 test principle of W3/060 use weighing method testing principle, in a certain temperature, make the both sides of the sample form specific humidity difference, water vapor permeability cup through the sample into the dry side and moisture vapor transmission cup by measuring weight variation with time, the parameters such as the water vapor transmittance of sample. 4. 2 sample moisture vapor transmission cup clamping to join a certain volume of distilled water, General moisture vapor transmission cup water in height between 1/2 and 2/3) , move or take, prevent water overflow; Add water to the cup after black rubber is placed flat washer, then light composite film sample ( Do not let the sample touch water, must not fold samples, ensure fully expanded) ； Put a good sample, and then placed a black rubber flat washer; And add the white teflon seal ring, cover the lid, tighten. Tighten after check whether pressure between white and black times, moisture vapor transmission cup with lid screw mouth good guarantee.